Intoxication. Most frequently alcohol intoxication. Alcohol abuse is up. Whipits while driving is way up, which is terrifying, I never encountered this prior to 2018, never. People on PCP drive better, at least they tend to top out at 35 mph.
After that, it gets complicated.
1. We have an aging population. The gray menace is real and demented drivers end up going the wrong way.
2. There are some changes in roadway design that people are having trouble adapting to. Traffic circles are appearing in the US, (finally). Locally we have an interchange where divided surface street traffic is routed so that motorists are driving on the left side of a divided road at the interface of surface streets and an interstate. It's more efficient if people don't screw up...
3. Changes in traffic enforcement. Almost nobody that you might want to be a cop, wants to be one. Our state troopers start at $100,000/year. There are 1000+ vacancies. Departments are shrinking. Departments told their officers to minimize proactive stops during COVID. Departments told employees to build the public trust with non-punitive activities but what the public wants is that when there is an impaired driver, they will be stopped and arrested.
Officers are human and too many became accustomed to doing too little. During the Michael Brown / George Floyd era, some good officers became hesitant to conduct traffic stops. Some departments encouraged their employees to focus more of their efforts on non-enforcement types of public service in order to build up the relationship with the community at large and their departments. It takes only a few years of this for the officer training a new hire to not actually know how to go out and make the traffic stops required to consistently locate and arrest impaired drivers. It's a numbers game. Between 7 pm and 5 am a certain percentage of drivers will be under the influence and so impaired as to be unable to safely operate a motor vehicle. The number of people caught is proportional to the number of drivers contacted. I guess this is the elephant in the room, IMO.
Circling back: alcohol and other drug abuse is up, all other factors being equal, wrong way drivers will be up.
Edit, right to left...